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A Textbook of Medicinal Chemistry – III


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  • ISBN: 9789395596077
  • Published : August 2022
  • Book Language : English
  • Edition : First
  • Format : Paperback
  • Pages : 336
  • Category:
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A Textbook of Medicinal Chemistry – III

It gives us immense pleasure to place before the T.Y.B.Pharm./VI semester pharmacy students the book on Medicinal Chemistry-III.
The Authors have made attempts in simplifying the chapters and presenting them in simple and easily understandable and graspable manner by the Students.
The book contains Five Units and an attempt has been made to provide pointwise syllabus which has been sequentially arranged to make the overall text easier and more enjoyable. The suitable diagrams and flow charts have been included to give good illustration of concepts. A special effort based upon previous University examination have been taken along with question paper pattern (as per PCI) during framework of each topics. Every chapter include the question bank along with MCQs to help the students to prepare better for upcoming examinations.
The book consist of five units which are divided into 12 chapters the book is written to cover all the topics in easy-to- Comprehensive manner with desired limit of the prescribed syllabus and it provide the students fundamentals aspect of Chemotherapeutic agents like Antibiotics, Antibacterial, Antimalarials,Anti-tubercular agents, Urinary antibacterial, Antiviral agents,Antifungals,Antiprotozoals, Anthelmintics, Sulphonamides etc. Some emphasize is given on the aspects of Drug design like Rational basis of drug design along with QSAR parameters along with Combinatorial Chemistry and its applications.

1. Antibiotics 

  • Antibiotics: Historical background, Nomenclature, Stereochemistry, Structure activity relationship, Chemical degradation classification and important products of the following classes.
  • β-Lactam antibiotics : Penicillin, Cepholosporins, β- Lactamase inhibitors, Monobactams.
  • Aminoglycosides : Streptomycin, Neomycin, Kanamycin.
  • Tetracyclines: Tetracycline, Oxytetracycline, Chlortetracycline, Minocycline, Doxycycline.

2. Macrolide Antibiotics 

  • Antibiotics: Historical background, Nomenclature, Stereochemistry, Structure activity relationship, Chemical degradation classification and important products of the following classes.
  • Macrolide: Erythromycin Clarithromycin, Azithromycin.
  • Miscellaneous: Chloramphenicol*, Clindamycin.

3. Prodrug Design 

  • Basic concepts and application of prodrugs design.

4. Antimalarial Agents 

  • Antimalarial: Etiology of malaria.
  • Quinolines : SAR, Quinine sulphate, Chloroquine*, Amodiaquine, Primaquine phosphate, Pamaquine*, Quinacrine hydrochloride, Mefloquine.
  • Biguanides and dihydro triazines: Cycloguanil pamoate, Proguanil.
  • Miscellaneous: Pyrimethamine, Artesunete, Artemether, Atovoquone

5. Anti-mycobacterial Agents (Anti tubercular agents)

  • Anti-tubercular Agents
  • Synthetic anti tubercular agents : Isoniozid*, Ethionamide, Ethambutol, Pyrazinamide, Para amino salicylic acid.*
  • Anti tubercular antibiotics : Rifampicin, Rifabutin, Cycloserine Streptomycine, Capreomycin sulphate.

6. Quinolone Antibacterial 

  • Urinary tract anti-infective agents
  • Quinolones: SAR of quinolones, Nalidixic Acid, Norfloxacin, Enoxacin, Ciprofloxacin*, Ofloxacin, Lomefloxacin, Sparfloxacin, Gatifloxacin, Moxifloxacin.

7. Antiviral Agents :

  • Amantadine hydrochloride, Rimantadine hydrochloride, Idoxuridine trifluoride, Acyclovir*, Gancyclovir, Zidovudine, Didanosine, Zalcitabine, Lamivudine, Loviride, Delavirding, Ribavirin, Saquinavir, Indinavir, Ritonavir.

8. Antifungal Agents 

  • Antifungal antibiotics : Amphotericin-B, Nystatin, Natamycin, Griseofulvin.
  • Synthetic antifungal agents : Clotrimazole, Econazole, Butoconazole, Oxiconazole Tioconozole, Miconazole*, Ketoconazole, Terconazole, Itraconazole, Fluconazole, Naftifine hydrochloride, Tolnaftate*.

9. Anti-protozoal Agents 

  • Metronidazole*, Tinidazole, Ornidazole, Diloxanide, Iodoquinol, Pentamidine Isethionate, Atovaquone, Eflornithine
  • Anthelmintics: Diethylcarbamazine citrate*, Thiabendazole, Mebendazole*, Albendazole, Niclosamide, Oxamniquine, Praziquantal, Ivermectin

10. Sulphonamides & Sulphones 

  • Historical development, chemistry, classification and SAR of Sulfonamides: Sulphamethizole, Sulfisoxazole, Sulphamethizine, Sulfacetamide*, Sulphapyridine, Sulfamethoxaole*, Sulphadiazine, Mefenide acetate, Sulfasalazine.
  • Folate reductase inhibitors: Trimethoprim*, Cotrimoxazole.
  • Sulfones: Dapsone*.

11. Drug Design 

  • Various approaches used in drug design.
  • Physicochemical parameters used in quantitative structure activity relationship (QSAR) such as partition coefficient, Hammet’s electronic parameter, Tafts steric parameter and Hansch analysis.
  • Pharmacophore modeling and docking techniques.

12. Combinatorial Chemistry 

  • Concept and applications chemistry: solid phase and solution phase synthesis.


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