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Pharmacy

Practical Medicinal Chemistry – I

B.PHARM (SEM. IV)

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  • ISBN: 9789395596268
  • Published : February 2023
  • Book Language : English
  • Edition : First
  • Format : Paperback
  • Pages : 70
  • Category:
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Rs.110.00

B.PHARM (SEM. IV)
PHARMACY
Practical Medicinal Chemistry – I

This Practical book is the best book of Medicinal Chemistry-I for S.Y.B. Pharmacy, Sem. IV as per Pharmacy Council of India, New Delhi which deals This book is the best Practical book of Medicinal Chemistry-I for S.Y.B. Pharmacy, Sem. IV as per Pharmacy Council of India, New Delhi which deals with Preparation of drugs/ intermediates, Assay of drugs, Determination of Partition coefficient.
This Practical Text book of Medicinal Chemistry-I content Four Sections, Ist Section content Preparation of drugs/ intermediates in which some synthesis like 1) 1,3-pyrazole, 2) 1,3-oxazole, 3) Benzimidazole, 4) Benztriazole,
5) 2,3- diphenyl quinoxaline, 6) Benzocaine, 7) Phenytoin, 8) Phenothiazine, 9) Barbiturate. Section IInd content Assay of drugs which included assay of 1) Chlorpromazine, 2) Phenobarbitone, 3) Atropine, 4) Ibuprofen, 5) Aspirin, 6) Furosemide. Section – IIIrd consist of Determination of Partition coefficient some drugs salicylic acid, ciprofloxacin and Sulfamethazine. Section IVth Introduction about ChemDraw.

 

I. Safety in Laboratory 

II. Some Medicinal Drugs and Intermediates Synthesis 
1. To prepare Benzimidazole from o-phenylenediamine.
2. To prepare Antipyrine (1,3 pyrazole derivative) from ethylacetoacetate and phenyl hydrazine.
3. To prepare Benzocaine from p-nitro toluene.
4. To prepare 5, 5-Diphenyl Hydantoin (Phenytoin) Sodium from benzophenone.
5. To prepare barbituric acid from urea.
6. To prepare benzotriazole from o-phenylenediamine.
7. To prepare 4-Benzylidene-2-phenyloxazol-5-one from Benzoylglycine.
8. To prepare phenothiazine from Diphenylamine.
9. To prepare 2,3 diphenyl quinoxaline from benzil.

III. Assay of some Medicinal Drugs 
10. To perform assay of Chlorpromazine Hydrochloride.
11. To perform assay of Atropine.
12. To perform assay of phenobarbitone.
13. To perform assay of Ibuprofen.
14. To perform assay of aspirin I.P.
15. To perform assay of furosemide.

IV. Determination of Partition coefficient of some drugs 
16. To determine the partition coefficient of salicylic acid between n-octanol and distilled water (Flask method).
17. To determine 1-octanol/water partition coefficients of ciprofloxacin by shake-flask method.
18. To determine 1-octanol/water partition coefficients of Sulfamethazine, sulfamethoxazole by shake-flask method.

V. ChemDraw 

VI. Computational tools in the medicinal chemistry 

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