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Practical Medicinal Chemistry – III


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  • ISBN: 9789395596275
  • Published : February 2023
  • Book Language : English
  • Edition : First
  • Format : Paperback
  • Pages : 63
  • Category:
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A Textbook of Medicinal Chemistry – III

This Practical book is the best book of Medicinal Chemistry – III for T.Y.B. Pharmacy, Sem. VI as per Pharmacy Council of India, New Delhi which deals Preparation of drugs / intermediates, microwave assisted synthesis, Assay of medicinal drugs, Introduction of Chem Draw Computational tools in the medicinal chemistry, Determination of physicochemical properties and Some Synthetic Schemes.
This Practical Text book of Medicinal Chemistry-III content Four Sections,Ist Section content Preparation of drugs/ intermediates in which some synthesis like 1) Sulphanilamide, 2) 7-Hydroxy, 4-methyl coumarin, 3) Chlorobutanol, 4) Triphenyl imidazole, 5) Tolbutamide, 6)Hexamine Section IInd content Assay of drugs which included assay of 1) Isonicotinic acid hydrazide, 2) Chloroquine , 3) Metronidazole, 4) Dapsone, 5) Chlorpheniramine maleate, 6)Benzyl penicillin. Section – IIIrd consists of Preparation of medicinally important compounds or intermediates by Microwave irradiation technique. Section IVth Drawing structures and reactions using chem draw. Section Vth content Determination of physicochemical properties such as logP, clogP, MR, Molecular weight, Hydrogen bond donors and acceptors for class of drugs course content using drug design software Drug likeliness screening (Lipinskies RO5).

I. Some Medicinal Drug and Intermediates Synthesis 
1. To prepare sulphanilamide from acetanilide.
2. To prepare 7-hydroxy-4-methyl coumarin from resorcinol.
3. To prepare of Chlorobutanol from acetone.
4. To prepare Triphenyl imidazole from Benzil.
5. To prepare tolbutamide from p-toluene sulfonamide.
6. To prepare hexamine from formaldehyde.

II. Assay of Some Medicinal Drugs 
7. To perform assay of Isoniazide tablet.
8. To perform assay of Chloroquine.
9. To perform assay of Metronidazole.
10. To perform assay of Dapsone.
11. To perform assay of Chlorpheniramine Maleate IP.
12. To perform assay of Crystalline Benzyl penicillin.

III. Microwave Assisted Synthesis 
13. Synthesis of Phenytoin by using microwave system.
14. Synthesis of tetrahydro pyrimidine by using microwave system.
15. Synthesis of Tetrahydrocarbazole by using microwave system.
16. Synthesis of aspirin from salicylic acid by using microwave system.
17. Synthesis of Paracetamol from aminophenol by using microwave system.

IV. Drawing structures and reactions using chem draw 


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